Royal Air Force Typhoon FGR4s have conducted a mission with French warplanes in a combined operation targeting an hidden munitions depot in Syria operated by the IS group, as stated by the UK Ministry of Defence.
The site, located using reconnaissance, was believed to be containing munitions and bombs, the statement said, and was located in mountainous terrain just above the historic site of Palmyra in Syria's central region.
"The RAF jets utilized Paveway IV guided bombs to strike a series of approach shafts providing entry to the site... early reports indicate the strike was effective," the ministry announced.
There was no sign of any civilian casualties in the attack on Saturday evening and each participating jet returned safely, the MoD added.
The Typhoon fighters were assisted by a Voyager refuelling tanker.
IS - referred to as ISIS - established extremist governance over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates our UK leadership, and resolve to stand shoulder to shoulder with our allies, to eradicate any resurgence of IS and their dangerous and violent ideologies in the region," the British Defence Secretary John Healey remarked.
British military aircraft have carried out patrols over Syria to "prevent any attempted comeback" of the group after its military defeat at the Baghuz confrontation in the year 2019, the ministry said.
"I extend gratitude to the personnel of the UK armed forces who took part in this operation for their expertise and their courage," the Defence Secretary added. "They were part of a great many British troops deployed over the festive period. This mission, to take out terrorist threats who endanger our way of life, shows how our armed forces are ready to step up, all year round, keeping Britain secure within its borders and strong abroad."
During December, the US military carried out what it described as a "massive strike" against Daesh sites in the country, following an assault resulted in the deaths of two American soldiers and a local interpreter in Palmyra.
The United Nations says Daesh still maintains roughly 5-7 thousand combatants in Syria and Iraq.